9knx

Structural highlights

Function

MPC2_HUMAN Mediates the uptake of pyruvate into mitochondria.^{[1] [2] [3] [4]}

References

1. ↑ Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012 Jul 6;337(6090):96-100. PMID:22628558 doi:10.1126/science.1218099
2. ↑ Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou JC. Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect. Mol Cell. 2015 Aug 6;59(3):491-501. PMID:26253029 doi:10.1016/j.molcel.2015.06.035
3. ↑ Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou JC. MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J Biol Chem. 2016 Aug 5;291(32):16448-61. PMID:27317664 doi:10.1074/jbc.M116.733840
4. ↑ Nagampalli RSK, Quesñay JEN, Adamoski D, Islam Z, Birch J, Sebinelli HG, Girard RMBM, Ascenção CFR, Fala AM, Pauletti BA, Consonni SR, de Oliveira JF, Silva ACT, Franchini KG, Leme AFP, Silber AM, Ciancaglini P, Moraes I, Dias SMG, Ambrosio ALB. Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter. Sci Rep. 2018 Feb 22;8(1):3510. PMID:29472561 doi:10.1038/s41598-018-21740-z