9koo

Structural highlights

Function

PCTA_PSEAE Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids, except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate.^{[1] [2] [3] [4]}

References

1. ↑ Shitashiro M, Tanaka H, Hong CS, Kuroda A, Takiguchi N, Ohtake H, Kato J. Identification of chemosensory proteins for trichloroethylene in Pseudomonas aeruginosa. J Biosci Bioeng. 2005 Apr;99(4):396-402. PMID:16233808 doi:http://dx.doi.org/10.1263/jbb.99.396
2. ↑ Rico-Jimenez M, Munoz-Martinez F, Garcia-Fontana C, Fernandez M, Morel B, Ortega A, Ramos JL, Krell T. Paralogous chemoreceptors mediate chemotaxis towards protein amino acids and the non-protein amino acid gamma-aminobutyrate (GABA). Mol Microbiol. 2013 Jun;88(6):1230-43. doi: 10.1111/mmi.12255. Epub 2013 May 22. PMID:23650915 doi:http://dx.doi.org/10.1111/mmi.12255
3. ↑ Kuroda A, Kumano T, Taguchi K, Nikata T, Kato J, Ohtake H. Molecular cloning and characterization of a chemotactic transducer gene in Pseudomonas aeruginosa. J Bacteriol. 1995 Dec;177(24):7019-25. PMID:8522505
4. ↑ Taguchi K, Fukutomi H, Kuroda A, Kato J, Ohtake H. Genetic identification of chemotactic transducers for amino acids in Pseudomonas aeruginosa. Microbiology. 1997 Oct;143 ( Pt 10):3223-9. PMID:9353923 doi:http://dx.doi.org/10.1099/00221287-143-10-3223