Structural highlights
Function
CAPSD_HEVBU Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.[UniProtKB:Q9YLQ9] Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (PubMed:14671114, PubMed:15557331). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (By similarity). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P33426][UniProtKB:Q81871][1] [2]
References
- ↑ Surjit M, Jameel S, Lal SK. The ORF2 protein of hepatitis E virus binds the 5' region of viral RNA. J Virol. 2004 Jan;78(1):320-8. PMID:14671114 doi:10.1128/jvi.78.1.320-328.2004
- ↑ Li SW, Zhang J, He ZQ, Gu Y, Liu RS, Lin J, Chen YX, Ng MH, Xia NS. Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid. J Biol Chem. 2005 Feb 4;280(5):3400-6. PMID:15557331 doi:10.1074/jbc.M410361200
