9m1y

Structural highlights

Function

K1C17_MOUSE Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.^{[1] [2] [3] [4] [5]}

References

1. ↑ Fan W, Yoon K. In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide-directed gene targeting. Exp Dermatol. 2003 Dec;12(6):832-42. PMID:14714564 doi:10.1111/j.0906-6705.2003.00099.x
2. ↑ Tong X, Coulombe PA. Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 2006 May 15;20(10):1353-64. PMID:16702408 doi:10.1101/gad.1387406
3. ↑ Kim S, Wong P, Coulombe PA. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature. 2006 May 18;441(7091):362-5. PMID:16710422 doi:10.1038/nature04659
4. ↑ Depianto D, Kerns ML, Dlugosz AA, Coulombe PA. Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet. 2010 Oct;42(10):910-4. PMID:20871598 doi:10.1038/ng.665
5. ↑ McGowan KM, Coulombe PA. Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol. 1998 Oct 19;143(2):469-86. PMID:9786956 doi:10.1083/jcb.143.2.469