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Structural highlights

Disease

RASM_HUMAN Noonan syndrome. The disease is caused by variants affecting the gene represented in this entry.

Function

RASM_HUMAN Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.^{[1] [2]}

References

1. ↑ Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell. 2006 Apr 21;22(2):217-30. doi: 10.1016/j.molcel.2006.03.027. PMID:16630891 doi:http://dx.doi.org/10.1016/j.molcel.2006.03.027
2. ↑ Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. JCI Insight. 2017 Mar 9;2(5):e91225. doi: 10.1172/jci.insight.91225. PMID:28289718 doi:http://dx.doi.org/10.1172/jci.insight.91225