9mfy

Structural highlights

Function

LIS1_YEAST Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. Following plus end binding, dynein may be offloaded to the cortex by NUM1. Required for viability in the absence of the kinesin-related microtubule-dependent motor protein CIN8.[HAMAP-Rule:MF_03141]^{[1] [2] [3]}

References

1. ↑ Lee WL, Oberle JR, Cooper JA. The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol. 2003 Feb 3;160(3):355-64. PMID:12566428 doi:10.1083/jcb.200209022
2. ↑ Li J, Lee WL, Cooper JA. NudEL targets dynein to microtubule ends through LIS1. Nat Cell Biol. 2005 Jul;7(7):686-90. PMID:15965467 doi:10.1038/ncb1273
3. ↑ Markus SM, Punch JJ, Lee WL. Motor cell cortex. Curr Biol. 2009 Feb 10;19(3):196-205. PMID:19185494 doi:10.1016/j.cub.2008.12.047