9mm3

Publication Abstract from PubMed

The rational design of molecular electronics remains a grand challenge of materials science. DNA nanotechnology has offered unmatched control over molecular geometry, but direct electronic functionalization is a challenge. Here a generalized method is presented for tuning the local band structure of DNA using transmetalation in metal-mediated base pairs (mmDNA). A method is developed for time-resolved X-ray diffraction using self-assembling DNA crystals to establish the exchange of Ag(+) and Hg(2+) in T:T base pairs driven by pH exchange. Transmetalation is tracked over six reaction phases as crystal pH is changed from pH 8.0 to 11.0, and vice versa. A detailed computational analysis of the electronic configuration and transmission in the ensuing crystal structures is then performed. This findings reveal a high conductance contrast in the lowest unoccupied molecular orbitals (LUMO) as a result of metalation. The ability to exchange single transition metal ions as a result of environmental stimuli heralds a means of modulating the conductance of DNA-based molecular electronics. In this way, both theoretical and experimental basis are established by which mmDNA can be leveraged to build rewritable memory devices and nanoelectronics.

Transmetalation for DNA-Based Molecular Electronics.,De A, Lu B, Ohayon YP, Woloszyn K, Livernois W, Perren L, Yang CF, Mao C, Botana AS, Hihath J, Canary JW, Sha R, Anantram MP, Vecchioni S Small. 2025 Jun;21(25):e2411518. doi: 10.1002/smll.202411518. Epub 2025 May 13. PMID:40364470^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.