9nel

Structural highlights

Function

PRIM_HHV11 Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011]^{[1] [2]}

References

1. ↑ Dracheva S, Koonin EV, Crute JJ. Identification of the primase active site of the herpes simplex virus type 1 helicase-primase. J Biol Chem. 1995 Jun 9;270(23):14148-53. PMID:7775476 doi:10.1074/jbc.270.23.14148
2. ↑ Klinedinst DK, Challberg MD. Helicase-primase complex of herpes simplex virus type 1: a mutation in the UL52 subunit abolishes primase activity. J Virol. 1994 Jun;68(6):3693-701. PMID:8189507 doi:10.1128/JVI.68.6.3693-3701.1994