Structural highlights
Disease
CHCH2_HUMAN The gene represented in this entry may be involved in disease pathogenesis.
Function
CHCH2_HUMAN Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788).[1]
References
- ↑ Aras S, Pak O, Sommer N, Finley R Jr, Huttemann M, Weissmann N, Grossman LI. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Nucleic Acids Res. 2013 Feb 1;41(4):2255-66. doi: 10.1093/nar/gks1454. Epub 2013 , Jan 8. PMID:23303788 doi:http://dx.doi.org/10.1093/nar/gks1454
