9p0p

Structural highlights

Function

CFR_STAAU Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics, such as chloramphenicol, florfenicol, clindamycin and linezolid.[HAMAP-Rule:MF_01873]^{[1] [2] [3]}

References

1. ↑ Kehrenberg C, Schwarz S, Jacobsen L, Hansen LH, Vester B. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol. 2005 Aug;57(4):1064-73. PMID:16091044 doi:10.1111/j.1365-2958.2005.04754.x
2. ↑ Mendes RE, Deshpande LM, Castanheira M, DiPersio J, Saubolle MA, Jones RN. First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother. 2008 Jun;52(6):2244-6. PMID:18391032 doi:10.1128/AAC.00231-08
3. ↑ Grove TL, Benner JS, Radle MI, Ahlum JH, Landgraf BJ, Krebs C, Booker SJ. A radically different mechanism for S-adenosylmethionine-dependent methyltransferases. Science. 2011 Apr 29;332(6029):604-7. doi: 10.1126/science.1200877. Epub 2011 Mar, 17. PMID:21415317 doi:http://dx.doi.org/10.1126/science.1200877