9qqv

Structural highlights

Function

PG057_VACCW Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell (PubMed:17475658, PubMed:27466413, PubMed:8999886). Produces the wrapped form of virus that is required for cell-to-cell spread (PubMed:27466413, PubMed:29540596). Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities (PubMed:9405398).^{[1] [2] [3] [4] [5]}

References

1. ↑ Honeychurch KM, Yang G, Jordan R, Hruby DE. The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus. J Virol. 2007 Jul;81(13):7310-5. PMID:17475658 doi:10.1128/JVI.00034-07
2. ↑ Sivan G, Weisberg AS, Americo JL, Moss B. Retrograde Transport from Early Endosomes to the trans-Golgi Network Enables Membrane Wrapping and Egress of Vaccinia Virus Virions. J Virol. 2016 Sep 12;90(19):8891-905. PMID:27466413 doi:10.1128/JVI.01114-16
3. ↑ Bryk P, Brewer MG, Ward BM. Vaccinia Virus Phospholipase Protein F13 Promotes Rapid Entry of Extracellular Virions into Cells. J Virol. 2018 May 14;92(11):e02154-17. PMID:29540596 doi:10.1128/JVI.02154-17
4. ↑ Grosenbach DW, Ulaeto DO, Hruby DE. Palmitylation of the vaccinia virus 37-kDa major envelope antigen. Identification of a conserved acceptor motif and biological relevance. J Biol Chem. 1997 Jan 17;272(3):1956-64. PMID:8999886 doi:10.1074/jbc.272.3.1956
5. ↑ Baek SH, Kwak JY, Lee SH, Lee T, Ryu SH, Uhlinger DJ, Lambeth JD. Lipase activities of p37, the major envelope protein of vaccinia virus. J Biol Chem. 1997 Dec 19;272(51):32042-9. PMID:9405398 doi:10.1074/jbc.272.51.32042