9qub

Structural highlights

Function

SL9B2_HUMAN Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:18508966, PubMed:22948142, PubMed:28154142, PubMed:36177733). Uses the proton gradient/membrane potential to extrude sodium (PubMed:22948142). Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity). Also able to mediate Na(+)/Li(+) antiporter activity in kidney (PubMed:22948142). May play a physiological role in renal tubular function and blood pressure homeostasis (By similarity). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).[UniProtKB:Q5BKR2]^{[1] [2] [3] [4] [5]}

References

1. ↑ Xiang M, Feng M, Muend S, Rao R. A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18677-81. PMID:18000046 doi:10.1073/pnas.0707120104
2. ↑ Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW. Characterization of the sodium/hydrogen exchanger NHA2. J Am Soc Nephrol. 2008 Aug;19(8):1547-56. PMID:18508966 doi:10.1681/ASN.2007111245
3. ↑ Kondapalli KC, Kallay LM, Muszelik M, Rao R. Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient. J Biol Chem. 2012 Oct 19;287(43):36239-50. PMID:22948142 doi:10.1074/jbc.M112.403550
4. ↑ Uzdavinys P, Coinçon M, Nji E, Ndi M, Winkelmann I, von Ballmoos C, Drew D. Dissecting the proton transport pathway in electrogenic Na(+)/H(+) antiporters. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1101-E1110. PMID:28154142 doi:10.1073/pnas.1614521114
5. ↑ Velázquez D, Průša V, Masrati G, Yariv E, Sychrova H, Ben-Tal N, Zimmermannova O. Allosteric links between the hydrophilic N-terminus and transmembrane core of human Na(+) /H(+) antiporter NHA2. Protein Sci. 2022 Dec;31(12):e4460. PMID:36177733 doi:10.1002/pro.4460