Structural highlights
Function
PON1_RABIT Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.[1]
References
- ↑ Watson CE, Draganov DI, Billecke SS, Bisgaier CL, La Du BN. Rabbits possess a serum paraoxonase polymorphism similar to the human Q192R. Pharmacogenetics. 2001 Mar;11(2):123-34. PMID:11266077 doi:10.1097/00008571-200103000-00003
