Structural highlights
Function
NCAP_SFTSV Encapsidates the genomic RNA, protecting it from nucleases (PubMed:23702688). Displays high affinity for single-stranded nucleic acid (PubMed:23702688). The encapsidated genomic RNA is termed the nucleocapsid (NC) or ribonucleoprotein (PubMed:23702688). The ribonucleoprotein has a non-helical structure (By similarity). Serves as template for viral transcription and replication. After replication, the nucleocapsid is recruited to the host Golgi apparatus by glycoprotein Gn for packaging into virus particles (By similarity).[UniProtKB:D3K5I7][UniProtKB:P21700][1]
References
- ↑ Zhou H, Sun Y, Wang Y, Liu M, Liu C, Wang W, Liu X, Li L, Deng F, Wang H, Guo Y, Lou Z. The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation. Protein Cell. 2013 Jun;4(6):445-55. PMID:23702688 doi:10.1007/s13238-013-3901-4
