Structural highlights
9v14 is a 1 chain structure with sequence from Pseudomonas sp. A2C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 0.93Å |
| Ligands: | , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
A2CH_PSEU6 Catalyzes the hydrolysis of the toxic natural product azetidine-2-carboxylate (an L-proline analog) by opening the azetidine ring to produce 2-hydroxy-4-aminobutanoate. Is thus involved in the detoxification of this compound but also in the degradation pathway of azetidine-2-carboxylate that allows Pseudomonas sp. A2C to grow on azetidine-2-carboxylate as the sole source of nitrogen. Does not show any detectable 2-haloacid dehalogenase activity with either (R)- or (S)-2-chloropropionate as the substrate, and is not able to hydrolyze L-proline.[1]
References
- ↑ Gross C, Felsheim R, Wackett LP. Genes and enzymes of azetidine-2-carboxylate metabolism: detoxification and assimilation of an antibiotic. J Bacteriol. 2008 Jul;190(14):4859-64. PMID:18487339 doi:10.1128/JB.02022-07
