9w96

Structural highlights

Function

BIOZ_AGRFC Involved in the formation of the biotin precursor pimeloyl-ACP (PubMed:33154364, PubMed:33824341). Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP (PubMed:33154364, PubMed:33824341).^{[1] [2]}

References

1. ↑ Hu Y, Cronan JE. α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism. Nat Commun. 2020 Nov 5;11(1):5598. PMID:33154364 doi:10.1038/s41467-020-19251-5
2. ↑ Zhang S, Xu Y, Guan H, Cui T, Liao Y, Wei W, Li J, Hassan BH, Zhang H, Jia X, Ouyang S, Feng Y. Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway. Nat Commun. 2021 Apr 6;12(1):2056. doi: 10.1038/s41467-021-22360-4. PMID:33824341 doi:http://dx.doi.org/10.1038/s41467-021-22360-4