9zfl

Structural highlights

Function

SC5A5_RAT Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:32084174, PubMed:8559252, PubMed:9341168). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:9341168).^{[1] [2] [3]}

References

1. ↑ Concilio SC, Zhekova HR, Noskov SY, Russell SJ. Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS). PLoS One. 2020 Feb 21;15(2):e0229085. doi: 10.1371/journal.pone.0229085. , eCollection 2020. PMID:32084174 doi:http://dx.doi.org/10.1371/journal.pone.0229085
2. ↑ Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996 Feb 1;379(6564):458-60. PMID:8559252 doi:http://dx.doi.org/10.1038/379458a0
3. ↑ Eskandari S, Loo DD, Dai G, Levy O, Wright EM, Carrasco N. Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity. J Biol Chem. 1997 Oct 24;272(43):27230-8. doi: 10.1074/jbc.272.43.27230. PMID:9341168 doi:http://dx.doi.org/10.1074/jbc.272.43.27230