Function
Amino acid oxidase catalyzes the oxidation of amino acids to the keto acid producing ammonia and hydrogen peroxide. These enzymes oxidize D-amino acids (DAO) and L-amino acids (LAO). The LAO oxidation products are 2-oxo acid, ammonia and hydrogen peroxide. LAO is widely found in snake venom.[1] DAOs oxidize neutral and basic D-amino acids.[2]
- L-amino acid oxidase/monooxigenase catalyzes both the oxidative deamination and oxidative decarboxylation of the alpha group of L-Lys producing keto acid and amide[3].
Relevance
Some DAOs are used in cancer therapy as inducers of oxidative stress and apoptosis. DAO and LAO use FAD as a cofactor.
Structural highlights
LAO structure contains 3 domains: domains. of L-amino acid oxidase (2jb1).[4] Water molecules are shown as red spheres.
3D structures of amino acid oxidase
Amino acid oxidase 3D structures
