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Ann Taylor/sandbox Norovirus oligosaccaride binding

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Binding of the Norovirus to fucose containing oligosaccarides

norovirus capsid binding to oligosaccarides

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References

  1. Hanisch FG, Hansman GS, Morozov V, Kunz C, Schroten H. Avidity of alpha-fucose on human milk oligosaccharides and blood group-unrelated oligo/polyfucoses is essential for potent norovirus-binding targets. J Biol Chem. 2018 Jul 27;293(30):11955-11965. doi: 10.1074/jbc.RA117.001369. Epub, 2018 Jun 1. PMID:29858242 doi:http://dx.doi.org/10.1074/jbc.RA117.001369
  2. Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang XC, Jiang X, Li X, Rao Z. Structural basis for the recognition of blood group trisaccharides by norovirus. J Virol. 2007 Jun;81(11):5949-57. Epub 2007 Mar 28. PMID:17392366 doi:10.1128/JVI.00219-07

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Ann Taylor

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