Cefuroxime, sold under the brand name Zinacef among others, is a second-generation cephalosporin[1] antibiotic used to treat and prevent a number of bacterial infections.[2] These include pneumonia, meningitis, otitis media, sepsis, urinary tract infections, and Lyme disease.[3] See also Cefuroxime.
Cefuroxime is active against many bacteria including susceptible strains of Staphylococci and Streptococci, as well as a range of gram negative organisms.[4] As with the other cephalosporins, it is susceptible to beta-lactamase, although as a second-generation variety, it is less so. Hence, it may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae, and Lyme disease. Unlike other second-generation cephalosporins, cefuroxime can cross the blood–brain barrier.[5]
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