Collagenase (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the Matrix metalloproteinase family.
- Collagenase G recognises and unravels collagen microfibrils into triple helices and unwind them[1].
- Collagenase H targets collagen III[2].
Relevance
Col is used for therapy of wounds, Dupuytren's contracture and Peyronie's disease.
Structural highlights
Clostridium histolycum collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a , a and an .[3] Water molecules are shown as red spheres. .
3D Structures of collagenase
Collagenase 3D structures
