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Complexin

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Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry 3rk3)

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3D structures of complexin

Updated on 07-July-2020

3rk3, 3rl0 - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human
1kil – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat
5w5c, 5w5d - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin

References

↑ Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:http://dx.doi.org/10.1074/jbc.M205044200
↑ Kummel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM. Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101. PMID:21785414 doi:10.1038/nsmb.2101