Function
Deoxycytidine kinase (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA (but not dT and dU) and nucleosides analogs which are used as antiviral and chemotherapeutic agents. [1]
Deoxyadenosine/deoxycytidine kinase (DACK) substrates ar cytidine, adenosine, arabinosylcytosine and arabinosyladenine [2].
Relevance
Deficiency of DCK causes resistance to antiviral and chemotherapeutic agents.
Structural highlights
The ability of (active site glutamates are in yellow).[3]
3D Structures of deoxycytidine kinase
Deoxycytidine kinase 3D structures