Image:Canonical wnt signaling pathway.jpg
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Fig. 3 – Canonical Wnt signal pathway: right – active Wnt pathway, left – inactive Wnt pathway, LPR5/6 – co-receptor interacts with Frizzled receptor through wnt molecule, DVL – Dishevelled protein inhibits degradation complex, CK1α - Casein kinase 1α phosphorylates β-catenin and allows binding of GSK3β, GSK3β - Glycogen synthase kinase 3β phosphorylates β-catenin and indicates it for degradation, APC - Adenomatous polyposis coli protein helps to binding of β-cateninu to CK1α and GSK3β, TCF/LEF – family of transcription factors, CBP - CREB-binding protein. Taken from [1]
- ↑ Zhang Y, Wang X. Targeting the Wnt/beta-catenin signaling pathway in cancer. J Hematol Oncol. 2020 Dec 4;13(1):165. doi: 10.1186/s13045-020-00990-3. PMID:33276800 doi:http://dx.doi.org/10.1186/s13045-020-00990-3
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| Date/Time | User | Dimensions | File size | Comment | |
|---|---|---|---|---|---|
| (current) | 21:29, 27 April 2022 | Kristína Galvánková (Talk | contribs) | 615×569 | 56 KB | Fig. 3 – Canonical Wnt signal pathway: right – active Wnt pathway, left – inactive Wnt pathway, LPR5/6 – co-receptor interacts with Frizzled receptor through wnt molecule, DVL – Dishevelled protein inhibits degradation complex, CK1α - Casein ki |
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