Mediator 3D structures

From Proteopedia

Updated on 17-December-2025

Mediator or mediator of RNA polymerase II transcription

7emf, 7enj, 8t9d, 8tqw – hMed in mediator complex – human – Cryo EM
7ena, 7enc – hMed in TFIID-mediator complex – Cryo EM
7lbm, 7nvr – hMed in transcription pre-initiation complex – Cryo EM
8trh – hMed in mediator complex + IDRC – Cryo EM
8gxs – hMed in mediator complex + nucleosome – Cryo EM
9m10, 9m11, 9m12, 9m13, 9m14, 9m15, 9m16, 9m17, 9m18, 9m19, 9m1a, 9m1b, 9m1c, 9m1d, 9vog, 9voh, 9voi, 9voj, 9vok, 9vol – hMed1 + vitamin D receptor + inhibitor
8tq2, 8tqc – hMed12 + Med13 + CDK8 kinase + cyclin C – Cryo EM
8j9a – hMed15 ABD3 domain 453-561 - NMR
2l23, 2l6u, 2ky6, 2xnf – hMed25 activator-interacting domain – NMR 9f76 – hMed23 – Cryo EM
9f6y – hMed23 + Elk-1 – Cryo EM
9ccv – hMed25 + NS1
5odd – hMed26 N terminal
6h02 – hMed23 + nanobody
6w1s, 8t1i, 8t1l – mMed in mediator complex – mouse – Cryo EM
8y4l – Med25 ACID domain 551-682 – Arabidopsis thaliana - NMR
8zz3 – yMed in mediator complex – yeast – Integrative
3rj1 – yMed6 + Med8 + Med11 + Med17 + Med18 + Med20 + Med22 7kpw – yMed12 – Cryo EM
7kpv, 7kpx – yMed12 + Med13 + SSN3 + suppressor of RNA polymerase – Cryo EM
4v1o – yMed in pre-initiation complex – Cryo EM
1yke, 1ykh – yMed7 + Med21 3fbi, 3fbn – yMed7 N terminal + Med31 2hzs – yMed8 C terminal + Med18 + Med20 3r84 - yMed11 + Med22 (mutant) 6aly – yMed 15 ABD2 residues 277-368
2lpb - yMed15 + general control protein GCN4 2hzm – yMed18 + Med20 5oqm – yMed + FTIIH in transcription pre-initiation complex – Cryo EM
5sva, 5u0s – fyMed in transcription pre-initiation complex – fission yeast – Cryo EM
5n9j, 5u0p – fyMed in mediator complex – Cryo EM
3c0t - fyMed8 C terminal + Med18 6xp5 – CtMed in head-middle complex – Chaetomium thermophilum – Cryo EM
7jmn – CtMed in tail complex – Cryo EM