Nucleoside diphosphate kinase
From Proteopedia
FunctionNucleoside diphosphate kinase (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is used for the synthesis of nucleoside triphosphates other than ATP[1]. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization. DiseaseNDKB deficiency causes diabetes-like vascular pathology[2]. Structural highlightsThe biological assembly of Human nucleoside diphosphate kinase is homohexamer. The NDK-adenine structure shows the two reaction products: ADP and phosphate[3]. Water molecules are shown as red spheres. Ca coordination site. 3D structures of nucleoside diphosphate kinaseNucleoside diphosphate kinase 3D structures
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References
- ↑ Janin J, Dumas C, Morera S, Xu Y, Meyer P, Chiadmi M, Cherfils J. Three-dimensional structure of nucleoside diphosphate kinase. J Bioenerg Biomembr. 2000 Jun;32(3):215-25. PMID:11768305
- ↑ Qiu Y, Zhao D, Butenschon VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 2016 Feb;53(1):81-9. doi: 10.1007/s00592-015-0752-x. Epub 2015 Apr, 23. PMID:25900369 doi:http://dx.doi.org/10.1007/s00592-015-0752-x
- ↑ Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:12972261
