Progestogens

From Proteopedia

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

Progesterone receptor. Human progesterone receptor ligand-binding domain bound with progesterone (1a28). Water molecules are shown as red spheres.

Progesterone is a negative allosteric modulator of nicotinic acetylcholine receptors, and a potent antagonist of the mineralocorticoid receptor.

Hydroxysteroid dehydrogenase, 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone.

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Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry 2w8y)

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References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky

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Progestogens

From Proteopedia

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