Proteasome 3D structures

7lsx – y13S core – yeast - Cryo EM

7ls6 – yP15S core - Cryo EM

4r3o, 5le5, 5lex – h20S core – human

6rgq, 6r70, 7pg9, 7v5g, 7v5m – h20S core – Cryo EM

1iru – b20S core - bovine

7dr7, 8zf5 – b20S core – Cryo EM

3une – m20S core – mouse

3unh – m20S core (immuno)

6tu3 – r20S core – rat - Cryo EM

7qve, 8amz – 20S – spinach - Cryo EM

3gpt, 3gpw, 1g0u, 5cz4 – y20S core

7ls5, 7tej – y20S core – Cryo EM

1ryp, 3wxr, 4qux, 4quy, 4qv0, 4qv1, 4qv3, 4qv4, 4qv5, 4qv6, 4qv7, 4qv8, 4qv9, 4y8r, 4y9y, 4ya1, 4ya4, 5bxl, 5cgf, 5cza, 5d0w, 5fg7, 6hwc - y20S core (mutant)

8t0m – y20S core (mutant) – Cryo EM

3c91, 3c92, 1pma, 3j9i, 5vy3, 6bdf, 5vy4, 8f6a – Ta20S core - Themoplasma acidophilum - Cryo EM

6utf, 6uti – Ta20S core subunits α+β – Cryo EM

8f66 – Ta20S core (mutant) – Cryo EM

3h4p – 20S core – Methanocaldococcus janaschii

2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis

1q5q - Re20S core

1j2q – Af20S core - Archaeoglobus fulgidus

6he7 – Af20S - Cryo EM

6qm8 – Lt20S core – Leishmania tarentolae - Cryo EM

6muw – Pf20S – Plasmodium falciparum - Cryo EM

3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis

3mka, 3hfa – Mt20S core (mutant)

6z46 – 20S core subunits α+β – Sulfolobus acidocaldarius

8adn – 20S – Vairimorpha necatrix - Cryo EM

7nan, 7nao, 7nap, 7yqc, 7yqd, 8cxb – h20S + PA28 activator – Cryo EM

6rey, 6kwy, 6xmj, 7naq, 8cvs – h20S + activator PA200 – Cryo EM

7qxn, 7qxp, 7qxu, 7qxw, 7qxx, 7qy7, 7qya, 7qyb – h20S + activator ZFAND5 – Cryo EM

7nht – h20S + akirin-2 – Cryo EM

7dr6, 7drw – b20S + activator – Cryo EM

4v7o, 5nif – y20S core+ Blm10

1z7q, 1fnt – y20S core+PA26

3ipm, 3jrm, 3jse, 3jtl, 1ya7, 1yar, 1yau - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U

5lzp - Mt20S subunits a+b + BPA - Cryo EM

6bgo, 6bgl – Mt20S + activator

6mux, 6muv – Pf20S + activator PA28 - Cryo EM

6hed, 6hec, 6hea, 6he9, 6he8, 6he5 – Af20S + PAN – Cryo EM

6utg, 6uth, 6utj – Ta20S core subunits α+β + activator PA26 – Cryo EM

4r67 – h20S + cancer drug

5ley, 5lf0, 5lf1, 5lf3, 5lf4, 5lf7, 5lez, 5lf6, 6avo, 6e5b, 7awe, 7b12 - h20S + inhibitor

5a0q - h20S + substrate analog

8fz6 – b20S core + PI31 inhibitor – Cryo EM

3unb, 3unf – m20S + inhibitor

3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3bdm, 2zcy, 2gpl, 2fak, 2f16, 1jd2, 1g65, 3mg0, 3mg4, 3mg6, 3mg7, 3mg8, 3oeu, 3oev, 3okj, 3shj, 3un4, 3un8, 3sdi, 3sdk, 4fzc, 4fzg, 4gk7, 4eu2, 4inr, 4int, 4inu, 4jsq, 4jsu, 4jt0, 4qwx, 4qzz, 4r17, 4r18, 4rur, 5ahj, 4y69, 4y6v, 4y6z, 4y70, 4y74, 4y75, 4y77, 4y78, 4y7w, 4y7x, 4y7y, 4y80, 4y81, 4y82, 4y8g, 4y8h, 4y8i, 4y8j, 4y8k, 4y8l, 4y8m, 5dki, 5dkj, 5l52, 5l54, 5l55, 4y6a, 4y84, 4y8n, 4y8o, 4y8p, 4y8q, 4y8s, 4y8t, 4y8u, 4y9z, 4ya0, 4ya2, 4ya3, 4ya5, 4ya7, 4ya9, 5jhr, 5jhs, 5lai, 4r02, 2zcy, 5bou, 5laj, 6gop, 6hwb, 6hwa, 6hw9, 6hw8, 6hw7, 6hw6, 6hw5, 6hw4, 6hw3, 6hw0, 6hvy, 6hvx, 6hvw, 6hvv, 6hvu, 6hvt, 6hvs, 6hvr, 6hva, 6hv7, 6hv5, 6hv4, 6hv3, 6huv, 6huu, 6huq, 6huc, 6hub, 6htr, 6htp, 6htd, 6htc, 6htb, 6h39, 7o2l – y20S core+inhibitor

4qxj, 4qz0, 4qz1, 4qz2, 4qz3, 4qz4, 4qz5, 4qz6, 4qz7, 4qzw, 4qzx, 4r00, 4r02, 5cgg, 5cgh, 5cgi, 5d0t, 5fgh, 6hwf, 6g8n, 6g8m, 6g7f – y20S (mutant) + inhibitor

4hnp, 4hrc, 4hrd, 4lqi, 4ltc, 4q1s, 6zou, 6zp6, 6zp8 - y20S core + antibiotics

4nnn, 4nnw, 4no1, 4no6, 4no8, 4no9, 4qby, 4qlq, 4qls, 4qlt, 4qlu, 4qlv - y20S core+ peptide inhibitor

5cz6, 5cz7 - y20S (mutant) + peptide inhibitor

7teo – y20S core + FUB1 – Cryo EM

3h6f, 3h6i, 3hf9, 2fhh, 3krd, 6ode, 6ocz, 6ocw, 6wnk – Mt20S core+inhibitor

8d6v, 8d6w, 8d6x, 8d6y – Mt20S core+ ATPase + ATP – Cryo EM

3nzj, 3nzw, 3nzx - y20S + TMC-95A mimic ligand

4qvl, 4qw4, 4z1l, 3tdd, 4j70 – y20S + cancer drug

4qvm, 4qvn, 4qvp, 4qvq, 4qvv, 4qvw, 4qvy, 4qw0, 4qw1, 4qw3, 4qw5, 4qw6, 4qw7, 4qwf, 4qwg, 4qwi, 4qwj, 4qwk, 4qwl, 4qwr, 4qws, 4qwu, 5cz8, 5cz9, 5fgd, 5fge, 5fgf, 5fgg, 5fgi, 5fhs, 5d0z, 5d0x, 5d0v, 5d0s, 5cz5, 5bxn, 6hwe, 6hwd - y20S (mutant) + cancer drug

4x6z - y20S + modulator

5gjq - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin

5l5a - y20S + h20S beta5i

5ltt - y20S + h20S beta5i + inhibitor

5l5b, 5l5r - y20S + h20S beta5i + h20S beta6

5l5w - y20S + h20S beta5c + h20S beta6

5l5x, 5l60, 5l61 - y20S + h20S beta5c + h20S beta6 + inhibitor

5l5y, 5l5z - y20S + h20S beta5c + h20S beta6 + cancer drug

5l5d, 5l5h, 5l5q, 5l5i, 5l5j, 5l5o, 5l5p, 5l5s, 5l5t, 5l5u, 5l5v, 5l62, 5l63, 5l64, 5l68, 5l69, 5l6a, 5l6c, 5m2b - y20S + h20S beta5i + h20S beta6 + inhibitor

5l5e, 5l5f - y20S + h20S beta5i + h20S beta6 + cancer drug

5l65, 5l66 - y20S + m20S beta5i + m20S beta6 + cancer drug

5l67, 5l6b - y20S + m20S beta5i + m20S beta6 + inhibitor

5fmg - Pf20S + inhibitor - Plasmodium falciparum - Cryo EM

5trr, 5trs, 5try, 5ts0, 5tho, 5trg - Mt20S + peptide

3h6f, 3h6i, 3hf9, 2fhh, 3krd, 6ode, 6ocz, 6ocw – Mt20S core+inhibitor

6qm7 – Lt20S + leishmania drug – Cryo EM

6td5 – Lt20S + inhibitor – Cryo EM

7lxt – Pf20S + cancer drug – Cryo EM

7lxu, 7lxv – Pf20S + inhibitor – Cryo EM

6tcz, 7zyj, 8olu – 20S + inhibitor - Leishmania donovani – Cryo EM

8f7k – Ta20S core + peptide – Cryo EM

2kqz, 2kr0 – hPRTS ubiquitin receptor domain

2ku1, 2ku2 – Taa-PRTS chains A-G

3fp9 – MtATPase chains A-L

7pxa - MtPRTS α+β subunits + ATPase – Cryo EM

7pxc, 7pxd - MtPRTS α+β subunits + ATPase + Pup – Cryo EM

2jay – MtPRTS β subunit

1j2p – AfPRTS α subunit

5nyw – PRTS β subunit – Yersinia bercovieri

7e55 - hPRTS α type-3 subunit – Cryo EM

6uyi, 6uyj - hPRTS subunit 1 + ubiquitin + ADRM1 – NMR

5l4k - hPRTS lid - Cryo EM

5dsv - hPRTS subunit a type-3

1p9c – hPRTS subunit 4 C-terminal

1p9d - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain

1uel - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR

1yx4 - hPRTS subunit 4 – NMR

1yx5, 1yx6, 2kde, 2kdf, 6mun - hPRTS subunit 4+ubiquitin – NMR

6u19 - hPRTS subunit 4 RAZUL domain + ubiquitin protein ligase E3A peptide – NMR

2o95, 2o96 - hPRTS subunit 7

3kw6 - hPRTS subunit 8

2krk - hPRTS subunit 8 – NMR

1qym, 1uoh - hPRTS subunit 10

1tr4 - hPRTS subunit 10 – NMR

4nik - hPRTS subunit 10 + scFv

7iuh - hPRTS subunit RPN1 + antibody – Cryo EM

7ujd - hPRTS subunit RPN1 + antibody + peptide – Cryo EM

6oi4 - hPRTS subunit RPN13+RPN2+ubiquitin

3t5x - hPRTS subunit Dss1 + PCI domain-containing protein 2

2dvw, 2dwz - mPRTS subunit 10 + hPRTS subunit 6B – mouse

3aji - mPRTS subunit 10 + subunit 4

2z59 - mPRTS subunit RPN13+ubiquitin

8jtk, 8jtl, 8pfd - PRTS subunit RPN10 + SAP05 – Arabidosis thaliana

2x5n - PRTS subunit RPN10 VWA domain – fission yeast

4ady - yPRTS subunit RPN2

5zmr - yPRTS subunit RPN5 N terminal – NMR

3vlf - yPRTS subunit 7 + DNA mismatch repair protein

4o8x, 4o8y, 5w83, 4owp - yPRTS subunit RPN8 + RPN11

4ocl, 4ocm, 4ocn - yPRTS subunit RPN8 + RPN11 + nanobody

5u4p - yPRTS subunit RPN8 + RPN11 + S31

2mr3 - yPRTS subunit RPN9 – NMR

2mqw - yPRTS subunit RPN9 N terminal – NMR

2mri - yPRTS subunit RPN9 C terminal – NMR

5ln1 - yPRTS subunit RPN10 + polyubiquitin

4b0z - yPRTS subunit RPN12

2z4d - yPRTS subunit RPN13

3vl1 - yPRTS subunit RPN14 (mutant)

3t5v, 5l3t, 5g5p, 4trq - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /

3txm, 3txn – PRTS subunit P42B – Drosophila melanogaster

5ubp - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator

5l4g, 5gjr, 5ln3, 5t0c, 5t0g, 5t0h, 5t0i, 5t0j, 5vhs, 5vhr, 5vhq, 5vhp, 5vho, 5vhn, 5vhm, 5vhj, 5vhi, 5vhh, 5vhf, 5vgz, 5vft, 5vfr, 5vfo - h26S - Cryo EM

6msb, 6msd, 6mse, 6msg, 6msh, 6msj, 6msk – h26S + ADP + ATP - Cryo EM

5m32 - h26S + inhibitor - Cryo EM

6wjd, 6wjn – h26S + ubiquitin + E3 ubiquitin ligase – Cryo EM

7w37, 7w38, 7w39, 7w3a, 7w3b, 7w3c, 7w3f, 7w3g, 7w3h, 7w3j, 7w3j, 7w3k, 7w3m – h26S + USP14 – Cryo EM

6epf, 6epe, 6epd, 6epc – r26S - Cryo EM

3j47, 4cr2, 4cr3, 4cr4, 5wvi, 5mpc, 6j2c, 6j2n, 6j2q, 6j2x, 6j30, 6fvt, 6fvu, 6fvv, 6fvw, 6fvx, 6fvy – y26S – Cryo EM

5wvk - y26S + ADP - Cryo EM

5mp9, 5mpa, 5mpd, 5mpe - y26S + ATP - Cryo EM

5mpb - y26S + AMPPNP - Cryo EM

4g4s – y26S + proteasome assembly chaperon 1 & 2

5a5b - y26S + UBP6 - Cryo EM

6ef3, 6ef2, 6ef1, 6ef0 – y26S + ubiquitin-L40 – Cryo EM

7qo3 – y26S + Ubp6 – Cryo EM

7qo4 – y26S + Ubp6 + UbVS – Cryo EM

7qo5, 7qo6 – y26S + Rpt1 + Rk + Ubp6 + UbVS – Cryo EM

8t08 – y26S + UMP1 + proteasome chaperone + proteasome assembly chaperone – Cryo EM