RING box protein (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex[1]. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction.
Relevance
Overexpression of RBX1 contributes to tumor progression and poor prognosis of non-muscle-invasive bladder transitional cell carcinoma[2]. RBX1 and RBX2 are overexpressed in multiple human cancer tissues and required for the growth and survival of cancer cells[3].
