RNA Interference

From Proteopedia

RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.

Schematic of RNAi Interference in Mammalian Cells

Articles in Proteopedia concerning RNA Interference include:

• • Suppression of RNA Silencing by Viruses
  • Plant Viral Protein p19 Supression of RNA Silencing
  • Tomato aspermy virus protein 2b Suppression of RNA Silencing
  • Flock house virus B2 protein Suppression of RNA Silencing

See RNAi in action by viewing this RNAi Animation.

To view automatically seeded indices concerning RNA Interference, see:

• • Argonaute
  • Dicer
  • Drosha
  • Piwi
  • RISC
  • RNAi
  • RNAi Suppression
  • RNA Interference
  • Slicer

To view other Proteopedia pages about diseases & drug targets, see: Pharmaceutical Drug Targets