Function
Ras GTPase-activating protein-binding protein (G3BP) is a stress-granule protein that nucletes stress-granule assembly. Stress-granules are sites of mRNA storage that form by stress conditions like viral infection [1].
Disease
G3BP1 can inhibit viral replication and can promote proliferation, invasion and methasthasis of cancer cells[2].
Relevance
Besides G3BP1 implication in cancer, it was found to be functional in neuronal development and maintainance. Hence G3BP1 may function in the progression of neurodegenerative diseases[3].
Structural highlights
G3BP1 contains an N-terminal nuclear transfer factor 2 (NTF2-like) domain, RNA recognition motif domain and Arg-Gly-rich region[4]. The 3D structure of the complex between G3BP1 and Semliki forest virus peptide shows protein:peptide ratio of 2:1. The viral peptide sequence contains twice the tetra peptide FGDF. Each FGDF sequence interacts with one molecule of G3PB1[5]. .
G3BP 3D structures
3D structures of G3BP