Reductive acetyl CoA pathway

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The reductive acetyl CoA pathway (CoA) pathway, also known as the Wood-Ljungdahl pathway uses CO2 as electron acceptor and carbon source, and H2 as an electron donor to form acetic acid. See Carbon Fixation.

The Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase is the oxygen-sensitive enzyme that permits the reduction of CO2 to CO and the synthesis of acetyl CoA in several reactions.


Carbon monoxide dehydrogenase showing Fe4-S4, Fe2-S2, Fe3-Ni-S4 clusters complex with butylformamide, butyl isocyanate and Fe+3 ion (PDB code 2yiv)

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References

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Alexander Berchansky

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