Function
Rho GTPase activating protein (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions[1],[2]. RhoGAPs contain a RhoGAP domain.
Relevance
RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy[3].
Structural highlights
The contains a and GDP[4]. Water molecules are shown as red spheres. .
3D structures of Rho GTPase activating protein
Rho GTPase activating protein 3D structures