SARS-CoV-2 protein ORF6

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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.
Model Confidence:

  Very high (pLDDT > 90)

  Confident (90 > pLDDT > 70)

  Low (70 > pLDDT > 50)

  Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.

To the right is an AlphaFold2 3D model of SARS CoV-2 Protein ORF6 (length = 61 amino acids, NCBI ID QHD43420.1) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 3[1].

Function

Open Reading Frame 6 (ORF6) Could be a determinant of virus virulence, since, when expressed in an otherwise attenuated JHM strain of murine coronavirus, it can dramatically increase the lethality of the latter. Seems to stimulate cellular DNA synthesis in vitro.[2][3]

Disease

Relevance

Structural highlights

Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein ORF6, rainbow color coded N-C (blue to red).
Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein ORF6, rainbow color coded N-C (blue to red)[1].

See also

Coronavirus_Disease 2019 (COVID-19)
SARS-CoV-2_virus_proteins
COVID-19 AlphaFold2 Models


SARS-CoV-2 Protein ORF6 Rank 1 model 3 from AlphaFold2
Drag the structure with the mouse to rotate

References

  1. ↑ 1.0 1.1 MIT ColabFold
  2. ↑ Modeling of the SARS-COV-2 Genome
  3. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman, Jaime Prilusky

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