Sandbox 1666

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CTX-M Beta-Lactamase

CTX-M Beta Lactamase is a class a enzyme. This enzyme creates drug resistance to ampicillin and cefotaxime through a two step process: deacylation and acylation.

Escherichia coli reca protein-bound DNA (PDB entry 3rec)

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References

Soeung V, Lu S, Hu L, Judge A, Sankaran B, Prasad BVV, Palzkill T. A drug-resistant β-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 Dec 25;295(52):18239-18255. doi: 10.1074/jbc.RA120.016103. Epub 2020 Oct 26. PMID: 33109613.

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