| Theoretical Model:
The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. |
Function
Host translation inhibitor nsp1.
Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.[1][2]
Disease
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Relevance
Structural highlights
Possible ATP binding site (residues 71, 73, 86, 106-108 with hydrophobicity coloring
