Sandbox 66
From Proteopedia
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| 1ca2, resolution 2.00Å () | |||||||||
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| Activity: | Carbonate dehydratase, with EC number 4.2.1.1 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Carbonic Anhydrase
Carbonic anhydrase enzymes are found in mammals, plants and bacteria. The alpha class relates to mammals. Carbonic Anhydrase enzymes are found in red blood cells and converts carbon dioxide to carbonic acid and bicarbonate ions. This enzyme also converts the acid and ions back to carbon dioxide which we breath out. This enzyme is not imperative for breathing process however it increases the rate of these conversions up to a million fold. Carbonic Anhydrase is classified as a metalloprotein because of its active site which contains a
History of Carbonic Anhydrase Carbonic Anhydrase was found in the red blood cells of cows in 1933. Throughout the years they have found three new classes of the enzyme. Alpha, beta and gamma are classes related to mammalian, plants and bacterial class.
Structure of Carbonic Anhydrase The structure of carbonic anhydrase is unique. Its active site which is a zinc ion is the key to the enzymes function. Zinc is a positive charged ion which allows it to break down the carbon dioxide. In the center of the structure there is a which is bound to three nitrogen atoms (,, and ).
Carbonic Anhydrase Structure
[1]
![[1]](http://proteopedia.org/wiki/index.php/Image:CA-rasmol.gif){kind=link}