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Function
Disease
Relevance
Structural highlights
Structurally, the N-terminal extracellular domain () and the 7TM comprise the signature seven helical structure
that is involved in the signaling via coupling to heterotrimeric proteins that activate adenylate cyclase to increase the levels of intracellular cyclic AMP, and also heterotrimeric G proteins that increase inositol phosphate and intracellular calcium levels.
Binding Pocket
Amino Acid sequence of Glucagon
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