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From Proteopedia

DNA polymerase nu Function

is the most recently discovered DNA polymerase in the human genome. Pol nu is a family A polymerase meaning that it is either a replicative or repair polymerase. It is most closely related to Escherichia coli pol I, human POLQ, and Drosophila Mus308. Although the specific biological functions are unknown, it is known that Pol nu is related to DNA repair and homologous recombination. Additionally, Pol nu plays a role in DNA translesion synthesis. Pol nu can perform translesion synthesis past thymine glycol which is a product of reactive oxygen species damage to DNA. Pol nu is able to perform translesion synthesis past thymine glycol while thymine glycol blocks most DNA polymerases during synthesis.

Pol nu Fidelity

Pol nu is one of the types of polymerases that is conserved in vertebrates, but it is error-prone, meaning it has low base substitution fidelity. During the replication process in the nucleus, specifically as Pol nu interacts with the DNA molecule at the of the finger domain on the protein, it discriminates poorly against the misinsertion of dNTP, specifically for guanine against thymine on the . Pol nu incorporates T opposite G on a template at a frequency of 0.45 which is a higher frequency than any other known DNA polymerase. This error is unusual for family A polymerases.