Sandbox Reserved 1357

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This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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Complex Between Nucleosome Core Particle and 146 BP Long DNA Fragment

Structure

1aoi is a complex that connects the nucleosome core particle and DNA fragment. It is considered a heterodecamer (10 chains). It has 5 macromolecules: 4 histones and 1 palindromic 146 bp DNA repeat organized in a super helix around the histones from the human X chromosome. The 4 histones are H2B,H4,H2A,H3. Nucleosomes are subunits of chromosomes. They are formed when the DNA wraps around the histones, resembling tiny “beads” all throughout the compact chromatin. There a millions and millions of nucleosomes scattered throughout our DNA ensuring that chromatin is packed tightly around the histones.

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are shown in purple in the middle of the molecule. These make up the heterodecamer structure of the molecule.

is shown in purple and surrounds the protein. This is just a snapshot of one section of DNA.

There are 6 manganese bound to the protein shown in green scattered throughout the molecule.

Function

The complex is a core nucleosome. The protein acts as a transcription regulator, repairs DNA, helps with DNA replication and chromosome remodeling. By winding the DNA around the histones, this complex makes DNA inaccessible for replication since the template strand is hidden. Because it prevents replication of DNA for various structures, complex, and processes, this protein not only regulates template dependent replication but also regulates transcription, DNA repair, and chromosomal stability. In order to make DNA accessible, the histones are phosphorylated.

References

1aoi. (2017, August 9). Retrieved February 21, 2018, from http://proteopedia.org/wiki/index.php/1aoiHistone

H2B 1.1. (2018, January 31). Retrieved February 21, 2018, from http://www.uniprot.org/uniprot/P02281

Luger, K., Richmond, R. K., Mader, A. W., & Sargent, D. F. (1997, January 01).

COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT. Retrieved February 21, 2018, from http://www.ebi.ac.uk/pdbe/entry/pdb/1aoi

Nucleosome/Nucleosomes. (n.d.). Retrieved February 21, 2018, from https://www.nature.com/scitable/definition/nucleosome-nucleosomes-30

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