Sandbox Reserved 1416

From Proteopedia

Jump to: navigation, search
This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Nucleosome complex (1aoi)

Insert caption here

Drag the structure with the mouse to rotate

Organism or Origin

1aoi, or the complex between nucleosome core particle (H3,h4,h2a,h2b) and 146 BP long DNA fragment, was originally found in the African clawed frog (Xenopus laevis).

Protein Structure

The histone complex is 418 amino acids long, and is made up of four pairs of polypeptides: , , , and . Alpha of all four core histones generate a positive charge, essential to the function of the protein.

Function

The function of this protein complex is to package DNA into compact nucleosomes. The phosphate backbone of DNA is negatively charged, which allows it to bind tightly to the positively charged histone.

Significance

This histone complex allows for the storage and retrieval of genetic material. While DNA is 'stored' in the nucleosome, it is inaccessible to transcription factors and other non-histone proteins. As a result, it plays a major role in transcription control. Additionally, this protein is found in a common testing organism, the African Clawed frog.


References

http://science.sciencemag.org/content/293/5532/1074.full https://www.nature.com/articles/38444

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1416"
Personal tools