Sandbox S1

1acj shows the crystal structure^[1] of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a reversible inhibitor of cholinesterase^[2]. It was the first FDA approved drug for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the of tryptophan 84 and phenylalanine 330 (W84 and F330). CNN

Function

Disease

Relevance

Structural highlights