The SMC5-6 protein complex is one of the three SMC (Structural maintenance of chromosomes) protein complexes present in all eukaryotes
[1],
[2]. The SMC5-6 complex is involved in chromatin dynamics such as the response to different types of DNA damage
[3],
[4] . The core of the complex is formed by the SMC5-SMC6 heterodimer, which is associated with four conserved non-SMC proteins
[5]. together with (homologue of Nse3) formed tight part of this complex.
.
Melanoma associated antigen (MAGE) proteins are associated also with DNA replication processes. This family of proteins contains more than 60 species divided into 6 families. As described in [6] the family is characterised by Coiled_coil .
Genes of these proteins were firstly indentified in varius kind of tumors. At this time their have been described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE conserved domain. The MAGE conserved domain is usually located close to the C-terminal, although it can also be found in a more central position in some proteins. The MAGE conserved domain is generally present as a single copy but it is duplicated in some proteins.
