Sandbox c99
From Proteopedia
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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.[1][2]
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
- ↑ Keighley MR, Asquith P, Edwards JA, Alexander-Williams J. The importance of an innervated and intact antrum and pylorus in preventing postoperative duodenogastric reflux and gastritis. Br J Surg. 1975 Oct;62(10):845-9. PMID:123
- ↑ Okoev GG, Kirakosian SA, Kagramanian RG. [Comparative evaluation of the course of labor after use of prostaglandin F2-alpha and oxytocin]. Akush Ginekol (Mosk). 1979 Jan;(1):17-8. PMID:434343
- ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
