1AGR has in total 4 chains. These are represented by 2 sequence-unique entities.1AGR is a tetramer structure of two identical duplicate crystal complex of RGS4- Gαi1 (tetramer excess stability of crystal structure).
Monomer structure of RGS4 in ribbon diagram: The RGS4 domain corresponds to an array of nine α-helices that fold into two small subdomains. The terminal subdomain contains the N and C termini of the box and is formed by α1, α2, α3, α8, and α9. Helices α1 and α9 lie in antiparallel orientation, juxtaposing the N and C termini of the box. The larger bundle subdomain, formed by α4, α5, α6, and α7, is a classic right-handed, antiparallel four-helix bundle. Both subdomains are required for GAP activity.
