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Small glutamine-rich tetratricopeptide repeat containing protein alpha

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Human SGTA TPR domain (PDB code 2vyi)

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3D structures of small glutamine-rich tetratricopeptide repeat containing protein α

Updated on 10-November-2020

4god, 4goe, 4gof - hSGTA dimerization domain residues 1-78 - human
4cpg - hSGTA dimerization domain - NMR
2vyi - hSGTA TPR domain 84-210
2lxb - ySGTA 2 dimerization domain - yeast
4asv - ySGTA 2 dimerization domain - NMR
2lxc, 4asw, 3zdm - ySGTA 2 dimerization domain + MDY2
5lyp - ySGTA 2 TPR domain 93-229
5lyn - ySGTA 2 TPR domain + peptide
3sz7 - SGTA 2 TPR domain 109-267 – Aspergillus fumigatus

References

  1. ↑ Shao S, Rodrigo-Brenni MC, Kivlen MH, Hegde RS. Mechanistic basis for a molecular triage reaction. Science. 2017 Jan 20;355(6322):298-302. doi: 10.1126/science.aah6130. PMID:28104892 doi:http://dx.doi.org/10.1126/science.aah6130
  2. ↑ Blatch GL, Lassle M. The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays. 1999 Nov;21(11):932-9. doi:, 10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N. PMID:10517866 doi:<932::AID-BIES5>3.0.CO;2-N http://dx.doi.org/10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N
  3. ↑ Dutta S, Tan YJ. Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1. Biochemistry. 2008 Sep 23;47(38):10123-31. Epub 2008 Aug 30. PMID:18759457 doi:http://dx.doi.org/10.1021/bi800758a
  4. ↑ Liou ST, Wang C. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. Arch Biochem Biophys. 2005 Mar 15;435(2):253-63. doi: 10.1016/j.abb.2004.12.020. PMID:15708368 doi:http://dx.doi.org/10.1016/j.abb.2004.12.020
  5. ↑ Walczak CP, Ravindran MS, Inoue T, Tsai B. A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum. PLoS Pathog. 2014 Mar 27;10(3):e1004007. doi: 10.1371/journal.ppat.1004007., eCollection 2014 Mar. PMID:24675744 doi:http://dx.doi.org/10.1371/journal.ppat.1004007

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Michal Harel

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