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- Image:E2020 interactins in AChE gorge.jpg (93 bytes)
1: E2020 interacting with AChE active-stie gorge, Fig5: Kryger et al (1999) Stru... - AChE inhibitors and substrates (53,646 bytes)
3: ==AChE substrate==
5: ...do californica''] [[acetylcholinesterase]] (''Tc''AChE) in 1991 <ref name="Sussman">PMID:1678899</ref> o...
7: ...d (Ser200, His440, and Glu327)</scene> (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2a...
9: ==AChE monovalent inhibitors==
15: ...are potent inhibitors which rapidly phosphonylate AChE and then may undergo an internal dealkylation rea... - Category:Torpedo ache (43 bytes)
1: List of pages with the keyword Torpedo ache - Category:Ache (35 bytes)
1: List of pages with the keyword Ache - Image:ACHE.pdb (32 bytes)
- Image:Hydrolyse ACh par AChE.jpg (14 bytes)
- Image:Sites de l'AChE.jpg (11 bytes)
- Sandbox AChE Adv JMol (1,042 bytes)
2: ...on='Caption for this structure' scene='10/1072244/Ache_jmol_adv/1'>
3: This is a default text for your page '''Sandbox AChE Adv JMol'''. Click above on '''edit this page''' ...
8: <scene name='10/1072244/Ache_jmol_adv/1'>like the opening secene</scene> - Sandbox AChE Surface (1,118 bytes)
2: ...on='Caption for this structure' scene='10/1072242/Ache_together_surf_cartoon/1'>
3: This is a default text for your page '''Sandbox AChE Surface'''. Click above on '''edit this page''' t...
8: ...ne name='10/1072242/Ache_together_surf_cartoon/1'>AChE - Surface white, 40% transparent, Cartoon Rainbow... - Treatments:AChE Inhibitor References (307 bytes)
- Image:AChE-Page-Cholinergic-Synapse.jpg (0 bytes)
- Image:AChE-Page-ACh shematic.JPG (0 bytes)
- Image:AChE-Page-schematic-gorge.jpg (0 bytes)
- Image:AChE-Page-schematic-fas.JPG (0 bytes)
- Image:AChE 7 26 11.m4v (90 bytes)
- Image:AChE FAS 7 26 11.m4v (91 bytes)
- Image:New Schematic AChE Fas.JPG (0 bytes)
- Image:Uniprot-search-hs-ache.png (0 bytes)
- AChE and Inhibition (13,318 bytes)
1: == '''AChE and Inhibition''' ==
2: ...40' side='right' caption='AChE from electric eel (PDB code [[1eea]])' scene=''>
8: ...l nervous system itself. Importance of the enzyme AChE is shown during inhibition with a nerve gas such ...
11: ...ly studied by pharmaceutical companies developing AChE inhibitors as a treatment for a number of disease...
14: ...necessary for this attachment and localization of AChE to the synapse of neuromuscular junctions <ref na... - Sandbox AChE (8,611 bytes)
1: ...che_with_ach/2' caption='Torpedo california AChE (PDB code [[2ace]])'>
3: ...) poisons is attributed primarily to their potent AChE inhibitors.
6: ...do californica''] [[acetylcholinesterase]] (''Tc''AChE) in 1991 opened up new horizons in research on an...
11: ...d (Ser200, His440, and Glu327)</scene> (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2a...
15: ...e various cholinesterase inhibitors interact with AChE can be see at [[Acetylcholinesterase: Treatment o...
Page text matches
- Acetylcholinesterase (8,905 bytes)
1: ...che_with_ach/2' caption='Torpedo california AChE (PDB code [[2ace]])'>
3: ...) poisons is attributed primarily to their potent AChE inhibitors.
8: ...do californica''] [[acetylcholinesterase]] (''Tc''AChE) in 1991 opened up new horizons in research on an...
13: ...d (Ser200, His440, and Glu327)</scene> (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2a...
18: ...e various cholinesterase inhibitors interact with AChE can be see at:<br /> - Sandbox Tst (3,047 bytes)
2: ... Scene ='1som/Ache_soman/1' side='right' caption='AChE complex with soman'>
8: (see also [[AChE inhibitors and substrates]], [[2wfz]], [[2wg0]], ...
11: ...nts is attributed primarily to their being potent AChE inhibitors.
14: ...are potent inhibitors which rapidly phosphonylate AChE and then may undergo an internal dealkylation rea...
18: ...sites of aged sarin-TcAChE ([[1cfj]]) and soman-TcAChE were essentially identical and provided structura... - Acetylcholine (3,078 bytes)
3: <applet load='Ach1.pdb' size='400' frame='true' align='right'
14: ...Ser200, His440, and Glu327)</scene> of (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2a... - 2jez (4,464 bytes)
7: ...6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SUN:O-[(R)-(DIMETHYLAMINO)(ETHOXY)PHOSPHORY...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jez ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jez ConSurf].
24: ...ystallographic and mass spectrometric analyses of AChE crystals. The results explain the relative reacti...
30: <div class="pdbe-citations 2jez" style="background-color:#fffaf0;... - 2jey (4,362 bytes)
7: ...-4-CARBAMOYLPYRIDINIUM'>HLO</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jey ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jey ConSurf].
24: ...ystallographic and mass spectrometric analyses of AChE crystals. The results explain the relative reacti...
30: <div class="pdbe-citations 2jey" style="background-color:#fffaf0;... - 2jf0 (4,421 bytes)
7: ...6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SUN:O-[(R)-(DIMETHYLAMINO)(ETHOXY)PHOSPHORY...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jf0 ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jf0 ConSurf].
24: ...ystallographic and mass spectrometric analyses of AChE crystals. The results explain the relative reacti...
30: <div class="pdbe-citations 2jf0" style="background-color:#fffaf0;... - Aricept Complexed with Acetylcholinesterase (4,526 bytes)
2: [[Image:E2020_interactins_in_AChE_gorge.jpg|left|250px]]<br />
4: (see also [[AChE inhibitors and substrates]])
6: ... for AChE, binding to both electric eel and mouse AChE in the nanomolar range.
11: The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/...
14: ...ity for AChE and a high degree of selectivity for AChE versus butyrylcholinesterase (BChE). It also deli... - Image:E2020 interactins in AChE gorge.jpg (93 bytes)
1: E2020 interacting with AChE active-stie gorge, Fig5: Kryger et al (1999) Stru... - 2c4h (4,831 bytes)
7: ...N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></t...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4h ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c4h ConSurf].
24: ...e structural insight into substrate inhibition in AChE at two different substrate concentrations. Our st...
30: <div class="pdbe-citations 2c4h" style="background-color:#fffaf0;... - 2c0p (4,886 bytes)
7: ...<td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene>...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0p ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0p ConSurf].
24: ...o the conformation found in the apo structure of mAChE. A hydrogen bond between the imidazole ring of Hi...
30: <div class="pdbe-citations 2c0p" style="background-color:#fffaf0;... - 2c0q (4,960 bytes)
7: ...IMETHYLPHOSPHONAMIDATE'>NTJ</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0q ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0q ConSurf].
24: ...o the conformation found in the apo structure of mAChE. A hydrogen bond between the imidazole ring of Hi...
30: <div class="pdbe-citations 2c0q" style="background-color:#fffaf0;... - 2c5g (4,315 bytes)
7: ...N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></t...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5g ProSAT]</span></td></tr>
18: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c5g ConSurf].
22: ...e structural insight into substrate inhibition in AChE at two different substrate concentrations. Our st...
28: <div class="pdbe-citations 2c5g" style="background-color:#fffaf0;... - 2c58 (4,852 bytes)
7: ...and=OAS:O-ACETYLSERINE'>OAS</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></t...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c58 ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c58 ConSurf].
24: ...e structural insight into substrate inhibition in AChE at two different substrate concentrations. Our st...
30: <div class="pdbe-citations 2c58" style="background-color:#fffaf0;... - 2jgf (5,030 bytes)
7: ...PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOS...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgf ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgf ConSurf].
24: ...y similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of H...
30: <div class="pdbe-citations 2jgf" style="background-color:#fffaf0;... - 2jgj (5,105 bytes)
7: ...Y)PHOSPHORYL]-L-SERINE'>SVV</scene>, <scene name='pdbligand=SVW:O-[(R)-AMINO(HYDROXY)PHOSPHORYL]-L-SERI...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgj ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgj ConSurf].
24: ...y similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of H...
30: <div class="pdbe-citations 2jgj" style="background-color:#fffaf0;... - 2jgm (4,902 bytes)
7: ...PROPYLPHOSPHORYLSERINE'>MIS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgm ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgm ConSurf].
24: ...y similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of H...
30: <div class="pdbe-citations 2jgm" style="background-color:#fffaf0;... - 2jgl (5,090 bytes)
7: ...PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SER...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgl ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgl ConSurf].
24: ...y similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of H...
30: <div class="pdbe-citations 2jgl" style="background-color:#fffaf0;... - 2jgi (4,986 bytes)
7: ...N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SVY:O-[BIS(1-METHYLETHOXY)PHOSPHORYL]-L-SER...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgi ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgi ConSurf].
24: ...y similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of H...
30: <div class="pdbe-citations 2jgi" style="background-color:#fffaf0;... - 2jgk (4,961 bytes)
7: ...6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SVZ:O-[(S)-HYDROXY(ISOPROPYLAMINO)PHOSPHORY...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgk ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgk ConSurf].
24: ...y similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of H...
30: <div class="pdbe-citations 2jgk" style="background-color:#fffaf0;... - 2jge (5,038 bytes)
7: ...Y)PHOSPHORYL]-L-SERINE'>SGR</scene>, <scene name='pdbligand=SGX:O-[(S)-AMINO(METHOXY)PHOSPHORYL]-L-SERI...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jge ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jge ConSurf].
24: ...y similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of H...
30: <div class="pdbe-citations 2jge" style="background-color:#fffaf0;...
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