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- 2jc7 (4,469 bytes)
2: ==The crystal structure of the carbapenemase OXA-24 reveals new insights into the mechanism of...
24: ...al structure that has been obtained for a class D carbapenemase enzyme. Accordingly, this information may help to...
26: Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of car...
33: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 9v4a (4,826 bytes)
2: ...borbactam (QPX7728) in complex with SME-1 class A carbapenemase==
11: ...prot.org/uniprot/BLAS1_SERMA BLAS1_SERMA] Class A beta-lactamase which confers resistance to the beta-lactam antib...
14: ... stereochemistry in the design of next-generation beta-lactamase inhibitors and diagnostics for AMR.
16: ...y Activity of Xeruborbactam against SME-1 Class A Carbapenemase.,Dhankhar K, S R Nair A, Hazra M, Alhmeidi Alkhat... - 9v49 (4,935 bytes)
11: ...prot.org/uniprot/BLAS1_SERMA BLAS1_SERMA] Class A beta-lactamase which confers resistance to the beta-lactam antib...
14: ... stereochemistry in the design of next-generation beta-lactamase inhibitors and diagnostics for AMR.
16: ...y Activity of Xeruborbactam against SME-1 Class A Carbapenemase.,Dhankhar K, S R Nair A, Hazra M, Alhmeidi Alkhat... - 8tn0 (3,969 bytes)
2: ==Crystal structure of KPC-44 carbapenemase w/o cryoprotectant==
14: Klebsiella pneumoniae carbapenemase 2 (KPC-2) is an important source of drug resistan...
16: Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resista... - 8tmt (4,329 bytes)
2: ==Crystal structure of KPC-44 carbapenemase in complex with vaborbactam==
14: Klebsiella pneumoniae carbapenemase 2 (KPC-2) is an important source of drug resistan...
16: Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resista... - 8tmr (4,152 bytes)
2: ==Crystal structure of KPC-44 carbapenemase complexed with avibactam==
14: Klebsiella pneumoniae carbapenemase 2 (KPC-2) is an important source of drug resistan...
16: Klebsiella pneumoniae carbapenemase variant 44 (KPC-44) acquires ceftazidime-avibacta... - 2ov5 (4,914 bytes)
2: ==Crystal structure of the KPC-2 carbapenemase==
24: ...to the carbapenemase activity of emerging class A beta-lactamases.
26: ...: insights into carbapenemase activity in class A beta-lactamases.,Ke W, Bethel CR, Thomson JM, Bonomo RA, van den...
33: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 1bue (4,639 bytes)
2: ==NMC-A CARBAPENEMASE FROM ENTEROBACTER CLOACAE==
23: ...e protein where the poorer substrates for class A beta-lactamases, such as cephamycins and carbapenems, need to be...
25: ...-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity.,Swaren P, Mavey...
32: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 4gnu (3,609 bytes)
2: ==Crystal structure of GES-5 carbapenemase==
14: ... takes place effectively in the case of the GES-5 beta-lactamase and significantly less so in GES-1. This informat...
16: ...d the carbapenemase activity in the GES family of beta-lactamases.,Smith CA, Frase H, Toth M, Kumarasiri M, Wiafe ...
23: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 7e9a (2,971 bytes)
12: ...vide a starting point to develop drugs combatting carbapenemases.
14: ...f 3-(alpha-acrylic acid) benzoxaboroles to combat carbapenemase resistance.,Xiao YC, Chen XP, Deng J, Yan YH, Zhu... - 4h8r (3,988 bytes)
2: ==Imipenem complex of GES-5 carbapenemase==
14: ... takes place effectively in the case of the GES-5 beta-lactamase and significantly less so in GES-1. This informat...
16: ...d the carbapenemase activity in the GES family of beta-lactamases.,Smith CA, Frase H, Toth M, Kumarasiri M, Wiafe ...
23: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 4gog (3,749 bytes)
12: ... takes place effectively in the case of the GES-5 beta-lactamase and significantly less so in GES-1. This informat...
14: ...d the carbapenemase activity in the GES family of beta-lactamases.,Smith CA, Frase H, Toth M, Kumarasiri M, Wiafe ...
21: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 1x8g (4,109 bytes)
2: ==Crystal Structure of the Mono-Zinc Carbapenemase CphA from Aeromonas Hydrophyla==
24: .... This will be relevant for the design of metallo-beta-lactamase inhibitors as well as of antibiotics that escape ...
26: ...yme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem.,Garau G, Bebr...
33: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 1x8h (4,164 bytes)
2: ==The Mono-Zinc Carbapenemase CphA (N220G mutant) Shows a Zn(II)- NH2 ARG Coord...
24: .... This will be relevant for the design of metallo-beta-lactamase inhibitors as well as of antibiotics that escape ...
26: ...yme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem.,Garau G, Bebr...
33: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 1x8i (2,845 bytes)
2: ==Crystal Structure of the Zinc Carbapenemase CphA in Complex with the Antibiotic Biapenem==
24: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 2gkl (4,146 bytes)
2: ==Crystal structure of the zinc carbapenemase CPHA in complex with the inhibitor pyridine-2,4-d...
24: ...ctive, nontoxic inhibitors of subclass B2 metallo-beta-lactamases.
26: Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.,Horsfall LE, Garau G, ...
33: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 4jf4 (3,356 bytes)
14: ... molecule to the acyl-enzyme species in imparting carbapenemase activity.
16: ...al Basis for Carbapenemase Activity of the OXA-23 beta-Lactamase from Acinetobacter baumannii.,Smith CA, Antunes N...
23: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - 2qds (4,464 bytes)
2: ==Crystal Structure of the Zinc Carbapenemase CPHA in Complex with the Inhibitor D-Captopril==
24: The development of broad-spectrum metallo-beta-lactamase (MBL) inhibitors is challenging due to structural...
26: ...asis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.,Lienard BM, Garau G, Horsfall L, Kars...
33: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] - Sandbox Lingyu (3,677 bytes)
4: ...exes as well as the kinetical characterization of beta-lactamases, antibiotics and inhibitors. The following short...
8: ...th an Gly170Asn/Ser substitution) have increasing carbapenemase activity, with the latter enzyme having the dubio... - 2qpn (5,255 bytes)
2: ==GES-1 beta-lactamase==
11: ...niprot/BLAG1_KLEPN BLAG1_KLEPN] Extended-spectrum beta-lactamase (ESBL) which confers resistance to penicillins, a...
24: ...rved in an identical location as in other class A beta-lactamases, interacting with the side chains of Ser70 and G...
26: ...enamase activity in the class A extended-spectrum beta-lactamases.,Smith CA, Caccamo M, Kantardjieff KA, Vakulenko...
33: *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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