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Article title matches
- Category:Crizotinib (41 bytes)
1: List of pages with the keyword Crizotinib - Image:Crizotinib Structure.png (32 bytes)
1: Structure of the drug Crizotinib
Page text matches
- 3zbf (4,763 bytes)
2: ...cture of Human ROS1 Kinase Domain in Complex with Crizotinib==
16: ...g cancers with ROS1 translocations. Resistance to crizotinib developed in a patient with metastatic lung adeno...
18: Acquired Resistance to Crizotinib from a Mutation in CD74-ROS1.,Awad MM, Katayama R... - 2wgj (7,760 bytes)
26: ... the lead series generated the clinical candidate crizotinib (PF-02341066), which demonstrated potent in vitro...
28: Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibi... - 2wkm (7,780 bytes)
26: ... the lead series generated the clinical candidate crizotinib (PF-02341066), which demonstrated potent in vitro...
28: Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibi... - 2xp2 (7,403 bytes)
2: ... Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)==
26: ... the lead series generated the clinical candidate crizotinib (PF-02341066), which demonstrated potent in vitro...
28: Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibi... - Category:Crizotinib (41 bytes)
1: List of pages with the keyword Crizotinib - 2yfx (6,261 bytes)
2: ...Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib==
16: ...inical PK and robust tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
18: ...s to overcome clinical ALK mutations resistant to crizotinib.,Huang Q, Johnson TW, Bailey S, Brooun A, Bunker ... - 2yhv (5,979 bytes)
15: ...inical PK and robust tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
17: ...s to overcome clinical ALK mutations resistant to crizotinib.,Huang Q, Johnson TW, Bailey S, Brooun A, Bunker ... - Student Project 7 for UMass Chemistry 423 Spring 2015 (14,430 bytes)
3: ='''MTH1/crizotinib'''=
9: ... align='right' caption='Basic Structure of MTH1/S-crizotinib' scene='48/483888/Basic/1' />
17: ...r in colon carcinoma cells is activated. When (S)-Crizotinib inhibits MTH1, the protein can no longer function...
20: ... align='right' caption='Basic Structure of MTH1/S-crizotinib 4c9x' scene='48/483888/Basic/1' />
22: <br> MTH1/S-crizotinib is a member of a protein family of phosphorohydro... - Sandbox Reserved 432 (8,052 bytes)
13: ...keeper L1196M mutation that occurs in response to crizotinib.<ref>DOI: 10.18632/oncotarget.2055</ref>
14: ... the point mutations created from a resistance to crizotinib.
16: ... created in response to the first generation drug crizotinib.
31: ...) gatekeeper mutation which would ultimately make crizotinib and alectinib obsolete ROS1 inhibitors. The cryst...
38: ...ibitors, PF-06463922 is 10-times more potent than crizotinib and foretinib and 100-fold more potent than eithe... - 4anl (5,979 bytes)
15: ...inical PK and robust tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
17: ...s to overcome clinical ALK mutations resistant to crizotinib.,Huang Q, Johnson TW, Bailey S, Brooun A, Bunker ... - 4anq (6,262 bytes)
2: ...Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib==
16: ...inical PK and robust tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
18: ...s to overcome clinical ALK mutations resistant to crizotinib.,Huang Q, Johnson TW, Bailey S, Brooun A, Bunker ... - 4ans (4,859 bytes)
2: ...Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib== - 4joa (6,216 bytes)
16: ... contrast to that of known ALK inhibitors such as Crizotinib and NVP-TAE684 which occupy the ribose binding po... - 4mkc (6,737 bytes)
16: ...ing marked efficacy of ceritinib in patients with crizotinib-resistant disease.
18: The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.,Friboul... - 4c9w (4,879 bytes)
2: ==Crystal structure of NUDT1 (MTH1) with R-crizotinib==
14: ... growth in animal models. Our results propose (S)-crizotinib as an attractive chemical entity for further pre-...
16: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.,Huber KV, Salah E, Rad... - 4c9x (4,851 bytes)
2: ==Crystal structure of NUDT1 (MTH1) with S-crizotinib==
14: ... growth in animal models. Our results propose (S)-crizotinib as an attractive chemical entity for further pre-...
16: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.,Huber KV, Salah E, Rad... - 4ccb (6,380 bytes)
16: ...inical PK and robust tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
18: ...s to overcome clinical ALK mutations resistant to crizotinib.,Huang Q, Johnson TW, Bailey S, Brooun A, Bunker ... - 4ccu (6,408 bytes)
16: ...inical PK and robust tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
18: ...s to overcome clinical ALK mutations resistant to crizotinib.,Huang Q, Johnson TW, Bailey S, Brooun A, Bunker ... - 4cd0 (6,454 bytes)
16: ...inical PK and robust tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
18: ...s to overcome clinical ALK mutations resistant to crizotinib.,Huang Q, Johnson TW, Bailey S, Brooun A, Bunker ... - 4cli (7,025 bytes)
16: Although crizotinib demonstrates robust efficacy in ALK positive NSCL...
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