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- Image:Flaps map.jvxl (0 bytes)
- Flaps Morph for HIV Protease (8,711 bytes)
1: ...350' side='right' caption='HIV protease: morph of flaps opening/closing ([[1hxw]] ↔ [[1tw7]]).' scen...
4: ...e to inhibitor drugs often involve changes to the flaps<ref name="wide-open" />. The ''active site expans...
6: ...>13 Å between isoleucine 50's at the tips of the flaps<ref name="wide-open" /> (but see [[4npt]] in the ...
13: ...ne> in <font color="orange">'''orange'''</font>. (Flaps: residues 42-58.)
14: .../13'>Morph of spacefilling rendition</scene> with flaps highlighted in <font color="orange">'''orange'''<...
Page text matches
- 2izo (5,287 bytes)
11: ...ts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to d... - 1b11 (5,148 bytes)
24: .... A significant difference in the location of the flaps in this region of the HIV-1 and FIV PRs correlate... - 1bve (12,077 bytes)
24: ...up the respective hinges and tips of the protease flaps. Flexibility of residues 4-8 may play a role in p... - 1bvg (12,090 bytes)
24: ...up the respective hinges and tips of the protease flaps. Flexibility of residues 4-8 may play a role in p... - 1hvh (11,461 bytes)
24: ...laps are flexible. The movement at the tip of the flaps could be as large as 7 A. On the basis of this ob... - 1kzk (11,591 bytes)
24: ...IV Pr inhibitors in which dynamic coupling of the flaps is offset by an increased level of motion of the ... - 1qbs (5,194 bytes)
22: ...ecule which is hydrogen bonded to both the mobile flaps of the enzyme and the two carbonyls flanking the ... - 1rq9 (5,820 bytes)
23: ...e-forming hydrogen bonds bridging between the two flaps and either the substrate or the peptide-based inh... - 1tw7 (4,144 bytes)
24: ...tion and amplified by additional mutations in the flaps of the protease, resulting in a "wide-open" struc... - 2fgu (11,914 bytes)
24: ...that Thr80 may play a role in the mobility of the flaps of protease. In the present study, both experimen... - 2fgv (11,916 bytes)
24: ...that Thr80 may play a role in the mobility of the flaps of protease. In the present study, both experimen... - 2fns (11,056 bytes)
24: ...es between the variants are evident only when the flaps are closed. Thus, a plausible structural model fo... - 2fnt (11,075 bytes)
24: ...es between the variants are evident only when the flaps are closed. Thus, a plausible structural model fo... - 2pc0 (4,994 bytes)
24: ...ude hinge motion of residues at either end of the flaps, opening and closing the entire beta-loop, and tr... - 2q3k (10,729 bytes)
24: ...nding interactions between the inhibitors and the flaps of the protease. Recently a new class of inhibito... - 3tlh (11,721 bytes)
24: .... A significant difference in the location of the flaps in this region of the HIV-1 and FIV PRs correlate... - 484d (4,145 bytes)
13: ...le formation, whereas the other is looped out and flaps over the bound peptide in the complex. The seven-... - 4hvp (10,736 bytes)
24: ...larly in an extended region corresponding to the "flaps" (residues 35 to 57 in each chain), where backbon... - 5fiv (5,234 bytes)
24: .... A significant difference in the location of the flaps in this region of the HIV-1 and FIV PRs correlate... - 5hvp (11,788 bytes)
24: ...bitor; hydrophobic side chains of residues in the flaps complete these binding sites.
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